منابع مشابه
Molecular interactions between Bos taurus interferon-τ1c and human type I interferon receptor
Interferon (IFN)-tau secreted only by ruminant endometrium, helps in maternal recognition of pregnancy and exhibit antiviral and antiproliferative activity. Among different types of IFN-tau, IFN-tau1c and IFN- tau3a are the most highly expressed isoforms. In the present study structure of INF-tau1c was predicted using homology modelling. The best model was selected based on overall stereo-chemi...
متن کاملType I Interferon in Human Autoimmunity
The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease (1). Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response against self antigens. Many investigator...
متن کاملInfluence of type-I Interferon receptor expression level on the response to type-I Interferons in human pancreatic cancer cells
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. Type-I interferons (e.g. IFN-α/-β) have several anti-tumour activities. Over the past few years, clinical studies evaluating the effect of adjuvant IFN-α therapy in pancreatic cancer yielded equivocal results. Although IFN-α and -β act via the type-I IFN receptor, the role of the number of receptors present on t...
متن کاملIdentification of a novel subunit of the type I interferon receptor localized to human chromosome 21.
Expression in mouse cells of the cloned human IFN alpha receptor (IFN alpha R) subunit selectively confers response and binding to human IFN alpha 8, indicating that other subunits are involved in IFN alpha binding. We report here that a new monoclonal antibody (mAb), termed IFNaR beta 1, recognizes a novel IFN alpha R subunit different from the one recently cloned and distinct from the alpha s...
متن کاملAcetylation-Dependent Signal Transduction for Type I Interferon Receptor
Cytokine-activated receptors initiate intracellular signaling by recruiting protein kinases that phosphorylate the receptors on tyrosine residues, thus enabling docking of SH2 domain-bearing activating factors. Here we report that in response to type 1 interferon (IFNalpha), IFNalpha receptors recruit cytoplasmic CREB-binding protein (CBP). By binding to IFNalphaR2 within the region where two a...
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ژورنال
عنوان ژورنال: Structure
سال: 2003
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(03)00120-5